Amino Acid Definition and Examples

Amino acids are important in biology, biochemistry, and medicine. They are considered to be the building blocks of polypeptides and proteins. Learn about their chemical composition, functions, abbreviations, and properties. Amino Acids An amino acid is an organic compound characterized by having a carboxyl group, amino group, and side-chain attached to a central carbon atom.Amino acids are used as precursors for other molecules in the body. Linking amino acids together forms polypeptides, which may become proteins.Amino acids are made from genetic code in the ribosomes of eukaryotic cells. The genetic code is a code for proteins made within cells. DNA is translated into RNA. Three bases (combinations of adenine, uracil, guanine, and cytosine) code for an amino acid. There is more than one code for most amino acids.Some amino acids may not be made by an organism. These essential amino acids must be present in the organisms diet.In addition, other metabolic processes convert molecules into amino acids. Amino Acid Definition An amino acid is a type of organic acid that contains a carboxyl  functional group (-COOH) and an amine functional group (-NH2) as well as a side chain (designated as R) that is specific to the individual amino acid. The elements found in all amino acids are carbon, hydrogen, oxygen, and nitrogen, but their side chains may contain other elements as well. Shorthand notation for amino acids may be either a three-letter abbreviation or a single letter. For example, valine may be indicated by V or val; histidine is H or his. Amino acids may function on their own, but more commonly act as monomers to form larger molecules. Linking a few amino acids together forms peptides, and a chain of many amino acids is called a polypeptide. Polypeptides may be modified and combine to become proteins. Creation of Proteins The process of producing proteins based on an RNA template is called translation. It occurs in the ribosomes of cells. There are 22 amino acids involved in protein production. These amino acids are considered to be proteinogenic. In addition to the proteinogenic amino acids, there are some amino acids that are not found in any protein. An example is the neurotransmitter gamma-aminobutyric acid. Typically, nonproteinogenic amino acids function in amino acid metabolism. The translation of genetic code involves 20 amino acids, which are called canonical amino acids or standard amino acids. For each amino acid, a series of three mRNA residues acts as a codon during translation (the genetic code). The other two amino acids found in proteins are pyrrolysine and selenocysteine. These are specially coded, usually by an mRNA codon that otherwise functions as a stop codon. Common Misspellings: ammino acid Examples of Amino Acids: lysine, glycine, tryptophan Functions of Amino Acids Because amino acids are used to build proteins, most of the human body consists of them. Their abundance is second only to water. Amino acids are used to build a variety of molecules and are used in neurotransmitter and lipid transport. Amino Acid Chirality Amino acids are capable of chirality, where the functional groups may be on either side of a C-C bond. In the natural world, most amino acids are the L-isomers. There are a few instances of D-isomers. An example is the polypeptide gramicidin, which consists of a mixture of D- and L-isomers. One and Three Letter Abbreviations The amino acids most commonly memorized and encountered in biochemistry are: Glycine, Gly, GValine, Val, VLeucine, Leu, LIsoeucine, Leu, LProline, Pro, PThreonine, Thr, TCysteine, Cys, C  Methionine, Met, MPhenylalanine, Phe, FTyrosine, Tyr, Y  Tryptophan, Trp, W  Arginine, Arg, RAspartate, Asp, DGlutamate, Glu, EAparagine, Asn, NGlutamine, Gln, QAparagine, Asn, N Properties of the Amino Acids The characteristics of the amino acids depend on the composition of their R side chain. Using the single-letter abbreviations: Polar or Hydrophilic: N, Q, S, T, K, R, H, D, ENon-Polar or Hydrophobic: A, V, L, I, P, Y, F, M, CContain Sulfur: C, MHydrogen Bonding: C, W, N, Q, S, T, Y, K, R, H, D, EIonizable: D, E, H, C, Y, K, RCyclic: PAromatic: F, W, Y (H also, but doesnt display much UV absorption)Aliphatic: G, A, V, L, I, PForms a Disulfide Bond: CAcidic (Positively Charged at Neutral pH): D, EBasic (Negatively Charged at Neutral pH): K, R